منابع مشابه
An Early Study on the Mechanisms that Allow Tissue-Engineered Vascular Grafts to Resist Intimal Hyperplasia
Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the study. Intimal hyperplasia in the outflow vein of TEVGs was assessed at the anasto...
متن کاملConnexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia
Venous bypass grafts often fail following arterial implantation due to excessive smooth muscle cells (VSMC) proliferation and consequent intimal hyperplasia (IH). Intercellular communication mediated by Connexins (Cx) regulates differentiation, growth and proliferation in various cell types. Microarray analysis of vein grafts in a model of bilateral rabbit jugular vein graft revealed Cx43 as an...
متن کاملTetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.
Decreased levels of tetrahydrobiopterin (BH4), an absolute cofactor for nitric oxide synthase (NOS), lead to uncoupling of NOS into a superoxide v. nitric oxide producing enzyme, and it is this uncoupling that links it to the development of vascular disease. However, the effects of in vivo deficiency of BH4 on neointimal formation after vascular injury have not been previously investigated. Hph...
متن کاملIntimal hyperplasia, vascular modeling, and the restenosis problem.
At the recent Scientific Sessions of the American Heart Association, a plenary session was devoted to the problem of restenosis after percu-taneous transluminal coronary angioplasty.' The panel included five widely recognized and experienced physician scientists who provided critical, comprehensive reviews of the problem. Two of the speakers dealt with the clinical, angiographic, and pathobiolo...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2000
ISSN: 1078-5884
DOI: 10.1053/ejvs.1999.1040